The death of actor Eric Dane, famous for his role as Dr. Mark “McSteamy” Sloan onGrey’s Anatomy, has renewed focus on Amyotrophic Lateral Sclerosis (ALS), a progressive neurological disease affecting motor neurons. ALS, also known as Lou Gehrig’s disease, gradually weakens voluntary muscles used for walking, speaking, eating, and breathing. Early symptoms, such as muscle weakness, twitching, slurred speech, frequent tripping, or difficulty swallowing, often go unnoticed, delaying diagnosis. While there is no cure, treatments can slow disease progression and improve quality of life through physical therapy, speech therapy, nutritional support, and breathing assistance. Awareness of ALS’s subtle early signs is critical, and Eric Dane’s story underscores the importance of timely medical attention, supportive care, and public knowledge about this life-altering disease.